Today, using motion capture devices is the most common way to create realistic human motion data. In addition to that, various methods have been proposed to edit, morph and retarget such kind of motion. However, there are still few methods to add physiological effects to motion which are caused by fatigue, injuries, muscle training and muscle shrinking. This is because the innate structure of the human body, such as the musculoskeletal system, has been mostly neglected when handling human motion in computer graphics. In this paper, we propose a method to use the musculoskeletal system of the human body for editing and retargeting human motion which were captured using a motion-capture device. Using our method, not only physiological effects such as fatigue, or injuries but also physical effects caused by external force can be added to human motion. By changing the muscular parameters and size of the body, it is also possible to retarget the motion to different bodies such as a very trained muscular body, weak and narrow body, or a small childish body.